diflucan mechanism of action

What do test results mean?

Q: Diagnosed DLE (discoid lupus) 2000, since then many symptoms like SLE, since recieving test results it's pointing to possible Sjogrens.
I have been tested 3 times in the last 5 years,
ANA titre between 1/320, 1/640 and the 320 again.

Now the last set of test were done in April 09,

This is what is written on the print out,

ANA pattern: speckled 1/320.
cytoplasmic speckled

the primary ANA is a nucleolar pattern. Nucleolar antibodies are most commonly seen in patients with scleroderma, SLE and raynauds phenomenon.

The primary indirect immunofluorescece pattern shows speckled staining of the cytoplasmic constituents, This may represent antibodies to ribosomes, endosomes, lysosomes or GW bodies or to mitochndria.

ENA results:Sjogren's Syndrome A/Ro 60 Antigen high positive

ENA interpretation:
This patient has autoantibodies to SS-A/Ro 60. These antibodies are most commonly seen in Sjogrens syndrome and SLE. the antibodies may also be seen in neonatal lupus syndrome and subacute cutaneous lupus.

I have been told that i don't have SLE.
But have not been told anything about these test results, what do they mean? Do i have Sjogrens? And what do all the SOMES mean.
I am so sick at times and yet i keep being told theres nothing wrong with me, but surely looking at these test results there is.

A:  Lab tests alone are not suffiecient to diagnose an autoimmune disorder. The most important is the history, symptoms over time, and family history. The physical exam and lab studies are additional clues. Discoid Lupus alone is not usually associated with systemic symptoms. A small number of DIL patients like yourself can develop SLE over time. One would not diagnose Sjogrens on a SSA Ab alone-it would depend on your symptoms. Hopefully, you have been evaluated by a Rheumatologist knowledgeable in Sjogrens. Also, consider being evaluated at one of the National Sjogrens Centers that is participating in the International SICCA Registry (UCSF, Johns Hopkins, Penn) and having a salivary gland biiopsy-they will be able then to tell you if you have Sjogrerns-and then you can figure out what is going on now.

Printed from: http://www.sjogrensforum.com/tests/what-do-test-results-mean/ .
© Your Name Here 2017.

1 Comment   »

  • Sandra waite says:

    Thank you, I do have many symptoms dry eyes, mouth not all the time but getting worse.
    I do have RA, muscle pain and lots of others.
    The tests were done by a Rheumie over a year ago and she said then that if the tests were negative she would'nt see me again, but there is something going on other wise my results would be fine, right.
    So i will push to see another Rheumie.
    Thank you for your help.

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